Anja Overdiek’s exploration of the ISLE model as a lens for systemic innovation in urban living labs (ULLs) involves the study of a municipal ULL in the Netherlands (Citylab X). She observes that European municipalities increasingly use ULLs for complex situations, demanding a paradigm shift from service design to systemic innovation and a transition approach. The ISLE model is proposed as a process that might support co-creation, provide a heuristic process framework, and mobilise knowledge across ULLs and related networks. The findings include considerations for systemic design practice in ULLs.